TITLE: Recent developments in modeling HIV infection and treatment

ABSTRACT: HIV infection is still a serious public health problem in the world. Highly active antiretroviral therapy can suppress viral replication to a very low level but cannot eradicate the virus. Mathematical models, combined with experimental data, have provided important insights into HIV dynamics, immune responses, and drug treatment. However, there are still a lot of questions that remain unanswered, for example, are some drugs more effective than others? whether treatment intensification brings benefits to patients? what causes multiple infection that may lead to drug resistance and immune escape? are there any other sources, besides the latent infection, that contribute to HIV persistence despite long-term therapy? In this talk, I will present our recent modeling efforts in addressing these issues and also discuss their implications for the management of HIV infection.